Glioblastoma Nutrition Diet

Glioblastoma is the most common and most aggressive form of brain cancer in humans today. In the mid-1990s research began on treatment using a ketogenic diet to slow the progression of malignant glioma cancer cell growth. The ketogenic diet was originally developed in the 1920s for the treatment of epilepsy in children, but through further research the process of ketosis has been found to help treat other neurological disorders as well.

Ketosis

Malignant tumors rely on glucose and glycolysis for growth and survival due to abnormalities in the number and function of their mitochondria. The ketogenic diet causes the brain to transition to ketone bodies, fats and proteins, as their primary energy source, and due to caloric restriction exploits the metabolic deficiencies of the cancer cells. At the same time, the increased fat and protein help to enhance the vitality of the normal neurons, as well as the rest of the body.

Ketogenic Diet

The ketogenic diet consists of high fat, moderate protein and low carbohydrate content, with restricted caloric intake. The ratio of fat and protein to carbohydrates is usually 4:1, with the intention of restricting the amount of glucose available to the malignant cancer cells in the brain in order to restrict tumor growth. Some simple tips for initiating the ketogenic diet include eating plenty of raw vegetables, because they are high in fiber and antioxidants. Avocados, eggs and cheese provide good amounts of fat and proteins as well as adding flavor to meals and can be used in several different recipes. Spaghetti squash can replace pasta, potatoes and rice in many recipes and will keep whole at room temperature for several weeks, providing a very low-carbohydrate dietary substitute.

Diet Implementation

The ketogenic diet begins with a 24-hour fasting period, where the patient consumes only water. During this period the healthy cells transition from reliance on glucose to fats and proteins for energy. The patient remains under close medical supervision during this period and works with a dietician throughout the diet. Even one meal off of the limits of the 4:1 ratio of fat to carbohydrates could reverse the positive effects of the ketogenic diet on cancer cell growth restriction.